Drug intelligence / Profile preview

silver-nanolipid complex

Development stage
Preclinical
Lead developer
Free University of Berlin
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Topical
01

Overview

**Silver-nanolipid complex** is a research-stage topical nanomedicine formulation composed of antimicrobial microsilver and negatively charged nanostructured lipid carriers in an oil-in-water cream or lotion. Silver ions released from microsilver adsorb to the lipid-nanoparticle surface, producing the proposed sNLC complex; nanoparticle adhesion increases local silver-ion retention at skin and bacterial surfaces, while the lipid carriers form an occlusive lipid film that supports restoration of the damaged stratum corneum barrier. The concept was developed for mild-to-moderate atopic dermatitis, particularly where abnormal bacterial colonization such as *Staphylococcus aureus* and impaired skin-barrier function contribute to disease. ([sciencedirect.com](https://www.sciencedirect.com/science/article/pii/S0378517313011204))

Brand names
Nanosensitive Cream forte
Other names
silver ion-nanolipid complexsilver-nanolipid complexsilver-NLC complexsilver–nanolipid complexsilver–NLC complexsNLC
02

Targets

Neuraminidase

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