Drug intelligence / Profile preview

silver nanoparticles

Development stage
Approved
Lead developer
Smith & Nephew
Modality
DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Nanoparticles → Drug Delivery Systems
Administration
Topical, Intravenous, Oral, Inhalation, Implant, Rectal, Intrathecal
01

Overview

Silver nanoparticles (AgNPs) are nanoscale particles of elemental silver with potent antimicrobial properties. They exert their effects primarily by disrupting microbial cell membranes, interfering with cellular respiration and metabolic processes, generating reactive oxygen species (free radicals), and releasing silver ions that bind to thiol groups in essential enzymes—leading to cell death. Silver nanoparticles can also interact with DNA and other cellular components. Clinically, AgNPs are used in wound dressings (e.g., Acticoat), burn treatments (e.g., Silvadene), and as adjunctive agents in cancer therapy (e.g., Cytolux). Their applications extend to drug delivery systems and tissue regeneration due to their large surface area and reactivity[1][2][3][4].

Brand names
ActicoatSilvadeneCytolux
Other names
AgNPs纳米银nanosilvercolloidal silver nanoparticles
02

Targets

NeuraminidaseATP Synthase

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