Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
silver nanoparticles reinforced double antibiotic paste
- Development stage
- Unknown
- Lead developer
- AIIMS New Delhi
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Silver nanoparticles reinforced double antibiotic paste (AgNP-DAP) is an experimental dental intracanal medicament developed by the All India Institute of Medical Sciences for the treatment of symptomatic apical periodontitis. The formulation combines a double antibiotic paste (DAP)—typically comprising ciprofloxacin and metronidazole—with silver nanoparticles to enhance antimicrobial efficacy against polymicrobial root canal infections and resistant biofilms. The silver nanoparticles provide a high surface-area-to-volume ratio, allowing for better penetration into dentinal tubules and disruption of bacterial cell membranes, while the antibiotics target bacterial DNA synthesis and replication. The paste is intended to reduce inflammatory biomarkers (such as IL-1β and MMP-9), alleviate post-endodontic pain, and promote periapical healing.
- Other names
- AgNP-DAPsilver nanoparticles reinforced DAPDAP+AgNPs
02
Targets
NeuraminidaseBacterial DNA gyrase / topoisomerase IV–DNA complexDNADNA gyrase
Beyond the preview
Go deeper on silver nanoparticles reinforced double antibiotic paste.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on silver nanoparticles reinforced double antibiotic paste.