silver sulfadiazine + chlorhexidine gluconate

Silver sulfadiazine + chlorhexidine gluconate is a topical combination drug used primarily for the prevention and treatment of infections in burn wounds and other skin injuries. Silver sulfadiazine is a sulfonamide antibiotic that releases silver ions, which disrupt bacterial cell walls and inhibit folic acid synthesis required for bacterial growth. Chlorhexidine gluconate is an antiseptic that disrupts microbial cell membranes, providing broad-spectrum antimicrobial activity. Together, they offer synergistic action against a wide range of gram-positive and gram-negative bacteria—including resistant strains—making this combination especially effective in reducing wound sepsis risk in burn patients. The product is typically formulated as a cream or ointment for external use only[1][2][5][7].

Brand names

Silvazine

Other names

silver sulfadiazine and chlorhexidine gluconate creamSSD + CHGsilver sulphadiazine + chlorhexidine digluconate