silybin-phosphatidylcholine

IDB 1016 is a phytosome formulation consisting of silybin, the primary active flavonolignan of milk thistle (Silybum marianum), complexed with phosphatidylcholine. Developed by Indena S.p.A., this complex is designed to significantly enhance the oral bioavailability and hepatoprotective activity of silybin, which otherwise suffers from poor gastrointestinal absorption. IDB 1016 has been investigated primarily for its antioxidant, anti-inflammatory, and antifibrotic properties in the treatment of chronic liver diseases, including chronic hepatitis C and non-alcoholic fatty liver disease (NAFLD). Its mechanism of action involves scavenging reactive oxygen species, inhibiting lipid peroxidation, and modulating inflammatory pathways such as the production of tumor necrosis factor (TNF) in hepatocytes.

Brand names

Siliphos

Other names

silybin phytosomesilybin-phospholipid complex