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SIM0388
- Development stage
- Phase 1
- Lead developer
- Jiangsu Simsheng Pharmaceutical
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intraperitoneal
01
Overview
SIM0388 is an investigational formulation consisting of **docetaxel encapsulated in polymeric micelles** for intraperitoneal use. It is designed for the treatment of **malignant ascites**, a common complication associated with advanced malignant tumors. The polymeric micelle technology aims to enhance the delivery and retention of docetaxel within the peritoneal cavity, potentially improving efficacy and reducing systemic toxicity. The mechanism of action is based on **docetaxel**, a cytotoxic agent that promotes microtubule stabilization and disrupts mitosis, leading to apoptosis of cancer cells. SIM0388 is currently in **Phase I clinical trials** to evaluate its safety, pharmacokinetics, and therapeutic efficacy when administered as an intraperitoneal perfusion in patients with malignant ascites. The trial sponsor and developer is Jiangsu Simcere Pharmaceutical.
- Brand names
- SIM0388SIM-0388SIM 0388
- Other names
- Docetaxel Polymeric Micelles
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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