Drug intelligence / Profile preview

Simbadol

Development stage
Unknown
Lead developer
Zoetis
Modality
Small Molecules
Administration
Subcutaneous
01

Overview

**Simbadol** is a veterinary brand name for a high-concentration buprenorphine injection (1.8 mg/mL) specifically formulated for subcutaneous administration in cats, providing 24-hour postoperative pain control with a single dose of 0.24 mg/kg. As a partial opioid agonist, it binds with high affinity to μ-opiate receptors in the central nervous system, delivering potent, long-acting analgesia due to slow receptor dissociation. Developed and manufactured by Zoetis, it is FDA-approved exclusively for cats undergoing surgical procedures and is a Schedule III controlled substance.[1][2][4][7][8]

Brand names
Simbadol
02

Targets

KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)

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