siMOB2

siMOB2 is a small interfering RNA (siRNA) designed to silence the expression of the human MOB kinase activator 2 (hMOB2) gene. hMOB2 is a cofactor associated with the NDR/Hippo signaling pathway and plays a role in the DNA damage response. In preclinical research, particularly in non-small-cell lung cancer (NSCLC) models, the depletion of hMOB2 using siMOB2 has been shown to sensitize cells to poly(ADP-ribose) polymerase (PARP) inhibitors such as olaparib and rucaparib. This sensitization is mediated through p53-dependent DNA damage signaling, leading to increased DNA strand breaks, persistent γH2AX accumulation, and caspase-3-dependent apoptosis. While hMOB2 loss alone is not intrinsically cytotoxic, its knockdown significantly reduces long-term clonogenic survival when combined with PARP inhibition in p53-functional lung cancer cells, suggesting its potential as a therapeutic strategy to overcome resistance in homologous recombination-proficient tumors.

Other names

hMOB2 siRNAhMOB-2 siRNAhMOB 2 siRNAMOB2 siRNAMOB-2 siRNAMOB 2 siRNAsmall interfering RNA targeting MOB2