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Simple syrup is a pharmaceutical solution consisting of sucrose in purified water, typically at a concentration of 85% w/v. In the context of clinical research conducted by Oregon Health and Science University (OHSU), it is utilized as a pharmacologically inactive placebo control in studies evaluating treatments for postoperative pain, such as gabapentin in pediatric spinal fusion patients. As a placebo, it is designed to match the appearance, viscosity, and taste of liquid drug formulations to maintain the integrity of double-blind study designs. It lacks therapeutic properties for pain management and serves as a baseline to measure the efficacy and safety of active interventions.
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