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siMT-2A_1

Development stage: Preclinical
Lead developer: National University of Singapore
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intraperitoneal

Overview

siMT-2A_1 is a chemically synthesized small interfering RNA (siRNA) duplex designed to target and silence the expression of the metallothionein-2A (MT-2A) isoform. Developed by researchers at the National University of Singapore, it has been utilized in preclinical research to investigate the role of MT-2A in breast cancer cell proliferation, chemoresistance, and interferon signaling. Silencing of MT-2A using siMT-2A_1 has been shown to reduce cell viability and enhance sensitivity to chemotherapeutic agents such as doxorubicin in MCF-7 breast cancer cells.

Targets

MTNR1B (Melatonin Receptor 2)

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