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simvastatin + coenzyme q10
- Development stage
- Phase 4
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Simvastatin + coenzyme Q10 is a combination therapy that pairs a cholesterol-lowering statin medication (simvastatin) with an antioxidant supplement (coenzyme Q10). This combination aims to maintain the cholesterol-lowering benefits of statins while potentially reducing statin-associated side effects, particularly muscle pain and weakness. Statins can lower the body's natural production of CoQ10, which some researchers believe contributes to muscle-related side effects. The combination therapy has shown promise in improving nitric oxide/reactive oxygen species balance in cardiovascular tissues and upregulating the Akt-eNOS pathway, which may represent a promising approach for treating cardiometabolic diseases.
- Other names
- SIMV+CoQ10simvastatin- and coenzyme-Q10-loaded polymeric nanoparticles
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NOS3 (eNOS)NOS1 (nNOS)AKT (RAC-alpha serine/threonine-protein kinase)
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