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simvastatin + ursodeoxycholic acid
- Development stage
- Unknown
- Lead developer
- Chang Gung Memorial Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Simvastatin + ursodeoxycholic acid is a combination therapy being evaluated in a Phase 2 clinical trial led by Chang Gung Memorial Hospital for the treatment of stable liver cirrhosis. Simvastatin is a small molecule HMG-CoA reductase inhibitor traditionally used for hypercholesterolemia, but it is being repurposed here for its pleiotropic effects, including the reduction of hepatic inflammation and fibrosis. Ursodeoxycholic acid (UDCA) is a naturally occurring bile acid used to treat cholestatic liver diseases. The study investigates whether the combination of these two agents can synergistically improve liver function, modulate the gut-liver axis by balancing gut microbiota, and normalize bile acid metabolism in patients who have achieved viral eradication or have inactive hepatitis.
- Brand names
- ZocorUrsoActigall
- Other names
- SimvastatinUrsodeoxycholic AcidUDCAsimvastatin-Chang Gung Memorial Hospital-liver cirrhosis
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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