sincalide

Sincalide is a synthetic peptide that corresponds to the C-terminal octapeptide of the naturally occurring hormone cholecystokinin (CCK). It acts as a diagnostic agent primarily used to stimulate gallbladder contraction and pancreatic secretion during diagnostic imaging or laboratory analysis. Sincalide is administered intravenously and mimics endogenous cholecystokinin by causing the gallbladder to contract, leading to bile evacuation similar to physiological processes. It also stimulates pancreatic secretion of bicarbonate and digestive enzymes, especially when combined with secretin. Additionally, sincalide accelerates intestinal transit of barium meals during radiological examinations, reducing radiation exposure time. Its main indications are for use in adults undergoing tests for gallbladder function (e.g., imaging or duodenal aspiration), assessment of pancreatic exocrine function (with secretin), and speeding up barium meal transit through the small intestine[1][2][4][5][6][7][8]. **Developers:** Ferring Pharmaceuticals **Manufacturers:** Ferring Pharmaceuticals, AVIR Pharma

Brand names

Kinevac

Other names

sincalidecholecystokinin octapeptidesynthetic cholecystokinin octapeptide