sinefungin

Sinefungin is a natural nucleoside analog isolated from Streptomyces species, structurally related to S‑adenosylmethionine and S‑adenosylhomocysteine. It acts as a potent competitive inhibitor of methyltransferases that use S‑adenosylmethionine as a methyl donor, including DNA methyltransferases (DNMTs), RNA methyltransferases (such as mRNA(guanine-N7)-methyltransferase and mRNA(nucleoside‑2′)-methyltransferase), and protein lysine methyltransferases like SET7/9. Through this inhibition, it blocks the transfer of methyl groups to DNA, RNA, or proteins. Biologically, sinefungin exhibits antifungal, antimicrobial, antiviral, and antiparasitic activities; it has shown efficacy against various fungi and protozoan parasites such as Leishmania spp., Trypanosomes, Plasmodium spp., Cryptosporidium parvum (notably in animal models), and can inhibit viral replication by targeting viral mRNA capping enzymes. Its main research applications are in epigenetics (as an inhibitor of histone H3K4 monomethylation) and infectious disease models[1][3][4][5][8].

Other names

sinefunginSinefunginaSinefungineAdenosyl-OrnithineA 9145, RP 32232