single-chain interleukin-12 messenger RNA

Single-chain interleukin-12 messenger RNA is an experimental **mRNA-based cytokine therapy** that encodes a single-chain form of interleukin-12 for transient expression after delivery into cells, most notably adoptively transferred tumor-reactive T cells by electroporation. In the provided study context, mouse and human T cells or tumor-infiltrating lymphocytes were engineered ex vivo with scIL-12 mRNA and then administered intratumorally, where locally produced IL-12 enhanced antitumor immunity, increased IFN-gamma production, improved cytotoxic function and persistence, and promoted endogenous immune activation. This is not a marketed drug with an established proprietary name; rather, it is a research-stage mRNA construct used as the active payload in transiently engineered cellular immunotherapy approaches, primarily for solid tumors.

Other names

single-chain interleukin-12 messenger RNAsingle-chain IL-12 mRNAscIL-12 mRNAscIL12 mRNAscIL 12 mRNAIL-12 mRNAIL12 mRNAIL 12 mRNA