Drug intelligence / Profile preview

Single oral dose of selected medicines, respectively

Development stage
Unknown
Lead developer
Medical University of Vienna
Modality
Small Molecules
Administration
Oral
01

Overview

"Single oral dose of selected medicines, respectively" is a non-specific clinical trial intervention placeholder used in a Phase 1 pilot study (NCT06710600) sponsored by the Medical University of Vienna. The study, titled "Phototox: Photosensitizing Potential of Common Medicines," was designed to systematically and quantitatively assess the photosensitizing potential of ten commonly prescribed oral medications with varying degrees of phototoxic potential in healthy volunteers. These ten medications include amiodarone, aspirin, diclofenac, doxycycline, enalapril, furosemide, hydrochlorothiazide, pantoprazole, verapamil, and voriconazole. The trial utilized a novel radiation and measurement protocol to evaluate phototoxic and photoallergic drug-induced skin reactions.

02

Targets

ACE (Angiotensin Converting Enzyme)ATP4A (Potassium–transporting ATPase alpha chain 1)CYP51A1 (Sterol 14α-demethylase)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)PGHS-1 (Prostaglandin G/H Synthase 1)NKCC2 (Sodium-potassium-chloride cotransporter 2)SLC12A2 (NKCC1)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)Bacterial RibosomeKCNA5 (Ultra-rapid delayed rectifier potassium channel)SCN5A (Sodium channel protein type 5 subunit alpha)Mitoribosome (Mitochondrial ribosome)

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