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sintilimab + cetuximab + mFOLFOX6 + FOLFIRI + CAPEOX + CAPIRI

Development stage: Unknown
Lead developer: Innovent Biologics
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous, Oral

Overview

A complex combination therapy approach incorporating the PD-1 inhibitor sintilimab, the EGFR inhibitor cetuximab, and multiple chemotherapy regimens (mFOLFOX6, FOLFIRI, CAPEOX, CAPIRI) that are commonly used in gastrointestinal cancers. This combination would theoretically target multiple pathways simultaneously, including immune checkpoint inhibition, EGFR signaling, and various cytotoxic mechanisms.

Targets

EGFR (Epidermal growth factor receptor)PDCD1 (Programmed cell death protein 1 receptor)

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