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sintilimab + MB07133

Development stage: Unknown
Lead developer: Innovent Biologics
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

Sintilimab + MB07133 is an investigational combination therapy for hepatocellular carcinoma (HCC). Sintilimab is a recombinant fully human anti-programmed death 1 (PD-1) monoclonal antibody that blocks the interaction of PD-1 with its ligand, while MB07133 is an intravenously administered cytarabine mononucleotide (araCMP) prodrug that functions as a DNA polymerase inhibitor. This combination approach likely leverages both immune checkpoint inhibition and direct interference with cancer cell DNA synthesis.

Targets

DNA polymerase familyPDCD1 (Programmed cell death protein 1 receptor)

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