SIOC-XJC-SF02

SIOC-XJC-SF02 is a **novel small molecule compound** classified as a *difluorinated alkoxy sulfonyl chloride* and is a structural derivative of fenofibrate. It was designed and evaluated for its **antitumor activity**, with a primary focus on liver cancer, particularly hepatocellular carcinoma (HCC). In vitro, SIOC-XJC-SF02 exhibits potent cytotoxicity against HepG2 and HCCLM3 human liver cancer cells, inducing apoptosis and inhibiting cell migration in a dose-dependent manner. In vivo, SIOC-XJC-SF02 significantly suppresses tumor growth in HepG2 cell xenografts in mice, showing efficacy comparable to 5-fluorouracil. The anti-liver cancer effect is associated with enhanced apoptosis, as indicated by increased caspase-3 and fumarate hydratase expression and reduced Ki-67 proliferation marker levels. The compound is an experimental agent with ongoing preclinical studies, and its precise molecular target is not explicitly identified, though its activity profile suggests mitochondrial and apoptotic regulation similar to other fenofibrate-related structures[1][2][4].