Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
siPHD1
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
siPHD1 is a small interfering RNA (siRNA) designed to target and silence the expression of prolyl hydroxylase domain-containing protein 1 (PHD1, also known as EGLN2). PHD1 is an oxygen-sensing enzyme that regulates the stability of hypoxia-inducible factor 1-alpha (HIF-1α) by targeting it for proteasomal degradation under normoxic conditions. In research settings, siPHD1 is widely utilized to investigate the role of PHD1 in cellular processes such as angiogenesis, cell cycle progression, and cell survival. For instance, silencing PHD1 in pancreatic islets has been shown to enhance VEGF secretion, improve islet viability, and restore glucose-stimulated insulin secretion, suggesting that targeting the PHD1 pathway could improve islet graft survival and function during transplantation.
- Other names
- PHD1 siRNAPHD-1 siRNAPHD 1 siRNAprolyl hydroxylase 1 siRNAsiRNA targeting PHD1
02
Targets
PHD1 (Prolyl hydroxylase domain-containing protein 1)
Beyond the preview
Go deeper on siPHD1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on siPHD1.