Drug intelligence / Profile preview

sIPV + MMR vaccine

Development stage
Unknown
Lead developer
Sinovac Biotech
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular, Subcutaneous
01

Overview

sIPV + MMR refers to a co-administration immunization strategy involving the Sabin-strain inactivated poliovirus vaccine (sIPV) developed by Sinovac Biotech and a measles-mumps-rubella (MMR) vaccine. The sIPV component is an inactivated biologic containing poliovirus types 1, 2, and 3 derived from Sabin strains, while the MMR component is a live attenuated vaccine targeting measles, mumps, and rubella viruses. This strategy is designed to improve childhood immunization coverage and reduce administrative costs by allowing simultaneous administration. Phase IV clinical trials published in 2026 demonstrated that co-administration in 18-month-old children is safe and produces non-inferior immune responses compared to separate administration, achieving 100% seroprotection for all poliovirus types and high seropositivity for measles, mumps, and rubella.

Other names
sIPV + MMRSabin-strain inactivated poliovirus vaccine and measles-mumps-rubella vaccine co-administration
02

Targets

E1/E2 (Rubella virus envelope glycoproteins)MV (Measles virus)Poliovirus type 1 capsid D-antigenPoliovirus type 2 capsid proteinPoliovirus type 3 capsid D-antigen

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