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siR-β-catenin
- Development stage
- Unknown
- Lead developer
- Alnylam Pharmaceuticals
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Intratumoral
01
Overview
siR-β-catenin (small interfering RNA targeting β-catenin) is a research-use-only double-stranded RNA molecule designed to silence the expression of the β-catenin gene (CTNNB1) via RNA interference (RNAi). β-catenin is a key intracellular signal transducer in the canonical Wnt signaling pathway and a structural component of cadherin-based cell-cell adhesion junctions. In research settings, siR-β-catenin is used to investigate the role of Wnt/β-catenin signaling in cellular processes such as proliferation, invasion, epithelial-mesenchymal transition (EMT), and drug resistance (e.g., to cisplatin) in various cancers, including breast cancer and hepatocellular carcinoma.
- Other names
- beta-catenin siRNAsiR-beta-cateninsiRNA targeting beta-cateninsmall interfering RNA targeting beta-catenin
02
Targets
CTNNB1 (Beta-catenin)
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