Drug intelligence / Profile preview

siraitia grosvenorii extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Siraitia grosvenorii extract, also known as monk fruit extract, is a natural substance derived from the fruit of the Siraitia grosvenorii vine. It is primarily known for its high content of mogrosides, which serve as non-caloric sweeteners. Beyond its use in the food industry, the extract is being researched for therapeutic applications in respiratory conditions such as chronic obstructive pulmonary disease (COPD). It demonstrates anti-inflammatory effects by inhibiting the MAPK and NF-κB signaling pathways, thereby reducing the production of pro-inflammatory cytokines and the infiltration of inflammatory cells like neutrophils and T cells into the airways. It also shows potential as an expectorant by increasing mucus secretion and regulating TRP channels (TRPV1 and TRPA1) involved in airway hyperresponsiveness.

Other names
monk fruit extractLuohan Guo extractmogroside extract
02

Targets

NF-κBTRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)MEK

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