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siRASA3
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, In Vitro
01
Overview
siRASA3 is a small interfering RNA (siRNA) designed to silence the expression of the RASA3 (RAS p21 protein activator 3) gene through RNA interference. RASA3 is a GTPase-activating protein (GAP) that serves as a critical negative regulator of Rap1 and Ras small GTPases, which are essential for platelet activation, integrin-mediated adhesion, and the maintenance of vascular endothelial stability. By reducing RASA3 protein levels, siRASA3 induces constitutive Rap1 activation, making it a valuable tool in research for studying the molecular mechanisms of thrombocytopenia, megakaryocyte differentiation, and hemorrhage. It is primarily utilized as a research-use-only (RUO) reagent in laboratory settings to investigate the functional consequences of RASA3 deficiency and is not currently associated with a specific clinical development program.
- Other names
- RASA3 siRNARASA-3 siRNARASA 3 siRNAsiRNA-RASA3siRNA-RASA-3siRNA-RASA 3si-RASA3si-RASA-3si-RASA 3
02
Targets
RASA3 (Ras GTPase-activating protein 3)
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