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siRhoB-2
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral, Intravenous
01
Overview
siRhoB-2 is a specific small interfering RNA (siRNA) sequence designed to target and silence the expression of the RhoB (Ras homolog family member B) gene. RhoB is a member of the Rho GTPase family that plays a complex role in cell signaling, often implicated in the malignant progression of various cancers, including cervical cancer. By facilitating the degradation of RhoB mRNA, siRhoB-2 effectively reduces RhoB protein levels, which has been shown in preclinical models to inhibit cancer cell proliferation, migration, and invasion. Additionally, silencing RhoB with siRhoB-2 appears to reverse epithelial-mesenchymal transition (EMT) markers and significantly enhance the sensitivity of cancer cells to cisplatin-induced apoptosis, making it a potential therapeutic tool or target for overcoming chemoresistance.
- Other names
- RhoB siRNA-2siRNA targeting RhoB sequence 2
02
Targets
RHOB (Ras homolog family member B)
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