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Siripus simplex, also known as Simple Syrup, is a pharmaceutical preparation consisting of a concentrated solution of sucrose in purified water. According to the British Pharmacopoeia (BP), it typically contains approximately 66.7% w/w sucrose. It is an inert pharmaceutical vehicle used primarily as a sweetening agent, base, or vehicle for liquid oral medications. In clinical research, such as the trial NCT03784105 conducted by Universitaire Ziekenhuizen KU Leuven (UZ Leuven), it is utilized as a placebo comparator to evaluate the physiological effects of active substances like codeine on pharyngeal and esophageal motility. It possesses no active pharmacological ingredients and no specific biological targets, serving as a control in randomized, double-blind studies.
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