siRNA-ACY1

siRNA-ACY1 is an experimental small interfering RNA (siRNA) therapeutic candidate designed to target and silence the expression of the Aminoacylase 1 (ACY1) gene. ACY1 is a zinc-binding enzyme involved in the hydrolysis of N-acylated amino acids and has been implicated in the progression of various malignancies, most notably hepatocellular carcinoma (HCC). siRNA-ACY1 functions through the RNA interference (RNAi) pathway, mediating the sequence-specific degradation of ACY1 mRNA, which results in reduced protein levels. Preclinical research has demonstrated that the knockdown of ACY1 using this construct can inhibit tumor cell proliferation, induce apoptosis, and suppress the migration and invasion of cancer cells in HCC models. While ACY1 is often considered a tumor suppressor in other contexts, such as renal cell carcinoma, its oncogenic potential in HCC makes it a viable target for RNA-based intervention. Currently, siRNA-ACY1 remains in the preclinical stage of development, primarily utilized in academic research to investigate the functional role of ACY1 in oncology.

Other names

ACY1 siRNAACY-1 siRNAACY 1 siRNAAminoacylase 1 siRNAAminoacylase1 siRNAAminoacylase-1 siRNAACY1-siRNAACY-1-siRNAACY 1-siRNA