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siRNA ETS1
- Development stage
- Preclinical
- Lead developer
- UVEG
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
siRNA ETS1 is a small interfering RNA (siRNA) designed to silence the expression of the ETS proto-oncogene 1 (ETS1) transcription factor. In the context of intestinal fibrosis and Crohn's disease research, it is utilized to investigate the role of ETS1 in regulating the senescence-associated secretory phenotype (SASP) and the activation of intestinal fibroblasts. By targeting ETS1 mRNA for degradation via the RNA interference (RNAi) pathway, it reduces ETS1 protein levels, which has been shown to decrease the expression of downstream factors such as IL-8 and BCL2. This molecule serves as a critical tool for understanding the molecular mechanisms of fibroblast-mediated tissue remodeling in inflammatory bowel diseases.
- Other names
- ets1-siRNAets-1-siRNAets 1-siRNAETS1 small interfering RNAETS-1 small interfering RNAETS 1 small interfering RNA
02
Targets
ETS1 (ETS proto-oncogene 1, transcription factor)
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