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siRNA-expressing plasmid DNA targeting G6Pase
- Development stage
- Preclinical
- Lead developer
- Chosun University
- Modality
- Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
siRNA-expressing plasmid DNA targeting G6Pase is an experimental gene therapy designed to lower blood glucose levels in diabetic models. It consists of a plasmid DNA vector that expresses small interfering RNA (siRNA) targeting glucose-6-phosphatase (G6Pase), a key enzyme in hepatic gluconeogenesis. By silencing G6Pase expression in the liver, the therapy aims to inhibit hepatic glucose production and reduce fasting blood glucose levels. It has been investigated in preclinical research, specifically in alloxan-induced diabetic mice, by researchers at Chosun University.
- Other names
- G6Pase siRNA-pDNAG-6Pase siRNA-pDNAG 6Pase siRNA-pDNAsiRNA-pDNA targeting G6Pase
02
Targets
G6PC1 (Glucose 6-phosphatase alpha)
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