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siRNA targeting GGH
- Development stage
- Preclinical
- Lead developer
- National Defense Medical Center
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous
01
Overview
siRNA targeting GGH is an experimental RNA interference (RNAi) therapeutic designed to silence the expression of gamma-glutamyl hydrolase (GGH). GGH is an enzyme involved in folylpolygamma-glutamate metabolism and has been identified as a prognostic biomarker and driver of malignancy in glioblastoma multiforme (GBM). By knocking down GGH, the siRNA disrupts proliferative stem-tumor cells, induces membrane disruption and necrotic changes, and inhibits tumor growth. Research indicates that GGH knockdown affects oxidative phosphorylation, MYC regulation, and reactive oxygen species (ROS) pathways, making it a potential target for treating resistant GBM.
- Other names
- GGH siRNAsiRNA-GGH
02
Targets
GGH (γ-glutamyl hydrolase)
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