siRNA targeting IRF3

siRNA targeting IRF3 is a therapeutic platform consisting of small interfering RNA (siRNA) designed to silence the expression of interferon regulatory factor 3 (IRF3). IRF3 is a key transcription factor involved in innate immune responses, type I interferon production, and tumor-driven immune evasion. In oncology, silencing IRF3 in the tumor microenvironment can inhibit the M2-type polarization of tumor-associated macrophages (TAMs) and suppress the secretion of CC motif chemokine ligand 22 (CCL22) by cancer cells, thereby reducing the recruitment of immunosuppressive regulatory T cells (Tregs). Preclinical research, such as that by Cursus Bio and Hanyang University, has explored delivering IRF3-targeting siRNA using lipid nano-assemblies (e.g., FD9R-GW/siIRF3) co-encapsulated with exosome release inhibitors like GW4869 to overcome exosome-mediated immune evasion and enhance antitumor immunity.

Other names

IRF3 siRNAIRF-3 siRNAIRF 3 siRNAsiIRF3siIRF-3siIRF 3siRNA targeting interferon regulatory factor 3