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siRNA targeting PRSS8
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
siRNA targeting PRSS8 is a short interfering RNA molecule designed to silence the expression of the **PRSS8** gene, which encodes the serine protease **prostasin**. In the context of esophageal squamous cell carcinoma (ESCC) research, this siRNA has been utilized as a laboratory tool to investigate the role of PRSS8 as a tumor suppressor. Studies have shown that PRSS8 expression is often downregulated in ESCC due to promoter hypermethylation, and restoring its expression inhibits cancer cell proliferation and migration. siRNA-mediated knockdown of PRSS8 is used in these experimental models to reverse the inhibitory effects of PRSS8 restoration, thereby confirming its functional significance in regulating epithelial-mesenchymal transition (EMT) and cell cycle progression.
- Other names
- PRSS8 siRNAPRSS-8 siRNAPRSS 8 siRNAsmall interfering RNA targeting PRSS8
02
Targets
Innate immune RNA sensorsPRSS1 (Trypsin family)
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