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siRNA targeting TBX2-AS1

Development stage: Preclinical
Lead developer: Children's Hospital of Philadelphia
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics

Overview

siRNA targeting TBX2-AS1 is a small interfering RNA designed to silence the expression of the long non-coding RNA (lncRNA) TBX2-AS1. Identified through integrative genomics in pediatric cancers, TBX2-AS1 is an oncogenic lncRNA that is highly expressed in neuroblastoma and is regulated by cancer-specific transcription factors. Preclinical research conducted at the Children's Hospital of Philadelphia and the University of Pennsylvania demonstrated that siRNA-mediated knockdown of TBX2-AS1 by over 90% significantly inhibits the growth of neuroblastoma cell lines. This suggests that TBX2-AS1 plays a critical role in tumor cell proliferation and may serve as a potential therapeutic target in pediatric solid tumors.

Other names: TBX2-AS1 siRNATBX-2-AS1 siRNATBX 2-AS1 siRNA

Targets

TBX2-AS1 (TBX2 antisense RNA 1)

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