Drug intelligence / Profile preview

siRNA targeting ZC3H12A

Development stage
Preclinical
Lead developer
KSQ Therapeutics
Modality
Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
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Overview

siRNA targeting ZC3H12A is a **research-stage RNA interference therapeutic approach** designed to reduce expression of the **ZC3H12A** gene, which encodes the RNase **monocyte chemotactic protein-induced protein 1**. Based on the provided context, this modality has been described in patent literature associated with **KSQ Therapeutics** as part of gene-regulating compositions intended to enhance immune effector cell function for **cancer immunotherapy**. The therapeutic concept is not a single named clinical asset but rather a set of small interfering RNA molecules, generally about 19 to 30 nucleotides in length, that hybridize to ZC3H12A mRNA and promote its silencing. By suppressing ZC3H12A, the approach is intended to modulate post-transcriptional immune regulation and potentially improve antitumor activity; published literature also supports ZC3H12A as a biologically relevant target in cancer, including small cell lung cancer radiosensitization.

Other names
ZC3H12A siRNAZC-3H12A siRNAZC 3H12A siRNAsiRNA targeting MCPIP1MCPIP1 siRNAMCPIP-1 siRNAMCPIP 1 siRNA
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Targets

ZC3H12A

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