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sirolimus + cyclophosphamide + topotecan
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of sirolimus (an mTOR inhibitor), cyclophosphamide (an alkylating agent), and topotecan (a topoisomerase I inhibitor). This oral regimen is administered on a metronomic schedule and has been studied primarily in pediatric and adolescent patients with relapsed or refractory solid tumors. The combination has demonstrated modulation of angiogenic pathways in biomarker studies.
02
Targets
mTOR (Mammalian target of rapamycin kinase)TOP1 (DNA Topoisomerase I)DNA
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