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SirPlux Duo
- Development stage
- Unknown
- Lead developer
- Advanced NanoTherapies
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems, Device-based Delivery → Drug Delivery Systems
- Administration
- Intra-arterial
01
Overview
SirPlux Duo is a next-generation drug-coated balloon (DCB) developed for the treatment of coronary artery disease (CAD) and peripheral artery disease (PAD). It uniquely delivers a dual-drug therapy of sirolimus and paclitaxel, co-encapsulated in biodegradable nanoparticles using Advanced NanoTherapies' proprietary platform. The device is engineered to provide stent-like vessel patency and prevent restenosis without leaving an implant behind. The nanoparticle formulation enables sustained, long-term release of both drugs at therapeutic levels directly at the lesion site, maximizing antiproliferative effects while minimizing cytotoxicity and distal embolization. This approach aims to combine the cytostatic mechanism of sirolimus with the antiproliferative action of paclitaxel for superior efficacy in inhibiting cell growth that leads to restenosis. Clinical development has focused on small vessel CAD, coronary in-stent restenosis, and peripheral below-the-knee lesions[1][2][3][5][6].
- Brand names
- SirPlux Duo
- Other names
- SirPlux Duo DCB
02
Targets
TUBB (Tubulin (alpha and beta subunits))Mechanistic target of rapamycin complex 1
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