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SIRT6-aav.017
- Development stage
- Preclinical
- Lead developer
- SirtLab
- Modality
- Gene Therapies
- Administration
- Intravenous
01
Overview
SIRT6-aav.017 is a recombinant adeno-associated virus (rAAV) gene therapy candidate developed by SirtLab for the treatment of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). The therapeutic approach involves the delivery of the SIRT6 gene to the central nervous system to achieve sustained expression of the SIRT6 protein. SIRT6 is a member of the sirtuin family of NAD+-dependent deacetylases that plays a critical role in DNA repair, genomic stability, and metabolic homeostasis. By enhancing SIRT6 levels, the therapy aims to provide neuroprotective effects and counteract the cellular aging processes associated with neurodegeneration. SIRT6-aav.017 is currently in preclinical development, having demonstrated proof-of-concept in animal models.
- Other names
- SIRT6-rAAVSIRT-6-rAAVSIRT 6-rAAVrAAV Alzheimer's DiseaserAAV Amyotrophic Lateral Sclerosis
02
Targets
SIRT6 (Sirtuin 6)
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