SIRT6-KD-ERC-Exos

SIRT6-KD-ERC-Exos are exosomes derived from endometrial regenerative cells (ERCs) in which *Sirtuin 6 (SIRT6)* expression is knocked down via shRNA transduction[1]. These exosomes have typical size and morphology for ERC-Exos and express exosome markers (CD9, CD63, TSG101), but minimal SIRT6 protein. In animal models, SIRT6-KD-ERC-Exos are used for mechanistic studies to distinguish the immunomodulatory and therapeutic effects of SIRT6-containing exosomes versus SIRT6-deficient versions. Specifically, compared to native ERC-Exos, SIRT6-KD-ERC-Exos show diminished ability to modulate CD4+ T cell differentiation, leading to less reduction of Th1 and Th17 infiltration, lower Treg induction, and less suppression of pro-inflammatory cytokines (e.g., IFN-γ, IL-17), indicating SIRT6's critical role in exosome-mediated alleviation of allograft rejection[1].

Other names

SIRT6-knockdown endometrial regenerative cell-derived exosomesSIRT-6-knockdown endometrial regenerative cell-derived exosomesSIRT 6-knockdown endometrial regenerative cell-derived exosomesSIRT6-KD-ERC-ExosSIRT-6-KD-ERC-ExosSIRT 6-KD-ERC-Exos