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SIRT6 shRNA
- Development stage
- Preclinical
- Lead developer
- University of Wisconsin–Madison
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
SIRT6 shRNA is a gene-silencing tool designed to knock down the expression of Sirtuin 6 (SIRT6), a nuclear deacetylase and mono-ADP-ribosyltransferase. In the context of oncology research, particularly melanoma, SIRT6 has been identified as an oncogenic factor that promotes cell proliferation and epithelial-mesenchymal transition (EMT). By utilizing lentiviral-mediated delivery of short hairpin RNA sequences targeting SIRT6 mRNA, researchers can achieve stable knockdown of the protein. This reduction in SIRT6 levels leads to the downregulation of mesenchymal markers (such as N-cadherin and vimentin) and the upregulation of epithelial markers (like E-cadherin), effectively inhibiting the migratory and invasive potential of cancer cells.
- Other names
- SIRT6 short hairpin RNASIRT-6 short hairpin RNASIRT 6 short hairpin RNAlentiviral SIRT6 shRNA
02
Targets
SIRT6 (Sirtuin 6)
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