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siSNAI
- Development stage
- Unknown
- Lead developer
- VA Wadsworth Medical Center
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
siSNAI is a small interfering RNA (siRNA) designed to knock down the expression of the SNAI gene, specifically SNAI1 (also known as Snail). SNAI1 is a zinc-finger transcription factor that plays a critical role in the epithelial-mesenchymal transition (EMT) and the regulation of 15-hydroxyprostaglandin dehydrogenase (PGDH) in various cancers, including pancreatic cancer. By silencing SNAI1, siSNAI reduces cellular proliferation and prostaglandin E2 (PGE2) production. Research indicates that SNAI1 acts as a transcriptional regulator of PGDH, and its knockdown can mimic or enhance the effects of other treatments, such as Vitamin D3, in suppressing pancreatic cancer cell growth.
- Other names
- SNAI siRNASnail siRNA
02
Targets
SNAI1 (Snail family transcriptional repressor 1)
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