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siSPARC

Development stage: Phase 2
Lead developer: National Skin Centre
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Injectable, Ophthalmic, Transdermal

Overview

siSPARC is a small interfering RNA (siRNA) therapy designed to silence the expression of SPARC (Secreted Protein Acidic and Rich in Cysteine), a matricellular protein associated with excessive collagen deposition and fibrosis. By reducing SPARC expression, siSPARC effectively decreases collagen production in tissues, making it a promising anti-fibrotic treatment. It has been formulated with various delivery systems including gelatin-tyramine hydrogels and hyaluronic acid microneedle patches to enhance stability, protection from RNase degradation, and cellular uptake.

Targets

SPARC (Secreted protein acidic and rich in cysteine)

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