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sisparc + silr4a
- Development stage
- Unknown
- Lead developer
- National Skin Centre
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Topical, Transdermal
01
Overview
sisparc + silr4a is a combination therapy delivered via a microneedle patch containing two small interfering RNAs (siRNAs): one targeting SPARC (Secreted Protein Acidic and Rich in Cysteine) and the other targeting LR4A. The formulation is designed for topical application to post-surgical scars, aiming to improve scar appearance by modulating extracellular matrix remodeling and fibrotic responses. The siSPARC component inhibits SPARC expression, which plays a key role in tissue repair, fibrosis, and collagen deposition. By suppressing SPARC, the therapy reduces collagen type I (COL1A1) levels and may limit excessive scarring. The addition of siLR4A targets another gene involved in wound healing or fibrosis pathways (exact target not fully detailed in available sources). This combination is being evaluated for its efficacy in reducing post-surgical scar formation using hydrolyzed RNA embedded within short microneedles for enhanced skin penetration[1][6][8].
- Other names
- siSPARC + siLR4A microneedle patch
02
Targets
SPARC (Secreted protein acidic and rich in cysteine)
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