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siSphK1
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral, Intravenous, Parenteral
01
Overview
siSphK1 is a small interfering RNA (siRNA) designed to target and silence the expression of sphingosine kinase 1 (SphK1). SphK1 is a key enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P), a bioactive lipid mediator that promotes cell survival, proliferation, migration, and angiogenesis. By knocking down SphK1 expression, siSphK1 reduces S1P levels and inhibits downstream signaling pathways such as Akt/mTOR, thereby suppressing cancer cell growth and promoting apoptosis. It is widely utilized as a research-use-only reagent in preclinical studies across various cancers, including breast, prostate, ovarian, and colorectal cancers.
- Other names
- SphK1 siRNASphK-1 siRNASphK 1 siRNAsphingosine kinase 1 siRNA
02
Targets
SPHK1 (Sphingosine kinase 1)
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