Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
sisunatovir + midazolam
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
PF-07941944 + midazolam is a drug combination used in clinical pharmacology studies to evaluate potential drug-drug interactions (DDI). **Sisunatovir** (PF-07941944, formerly RV521) is an orally bioavailable small molecule inhibitor of the Respiratory Syncytial Virus (RSV) fusion (F) protein. Originally developed by ReViral and subsequently acquired by Pfizer, sisunatovir acts by preventing the RSV envelope from fusing with the host cell membrane, thereby blocking viral entry and replication. **Midazolam** is a short-acting benzodiazepine that serves as a sensitive probe substrate for the cytochrome P450 3A4 (CYP3A4) enzyme. In clinical trials, this combination is administered to healthy participants to determine if sisunatovir acts as an inhibitor or inducer of CYP3A4 by measuring changes in the pharmacokinetics of midazolam.
- Other names
- sisunatovir + midazolam
02
Targets
CYP3A4 (Cytochrome P450 3A4)GABRR (GABA-A receptor subunit rho)
Beyond the preview
Go deeper on sisunatovir + midazolam.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on sisunatovir + midazolam.