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siYAP1
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
siYAP1 is a small interfering RNA (siRNA) designed to target and silence the expression of Yes-associated protein 1 (YAP1), a key transcriptional coactivator in the Hippo signaling pathway. In preclinical research, siYAP1 is widely used as a laboratory tool to investigate the role of YAP1 in various pathological processes, including oncology, tissue regeneration, and fibrotic diseases. For instance, researchers have utilized nanoparticle-delivered siYAP1 (such as HA-PEI/siYap1) to target liver sinusoidal endothelial cells (LSECs) to inhibit YAP1 expression, which has been shown to alleviate LSEC capillarization, hepatocyte death, and liver fibrosis in animal models.
- Other names
- siRNA targeting YAP1siYap1siYap-1siYap 1YAP1 siRNAYAP-1 siRNAYAP 1 siRNAYAP1 small interfering RNAYAP-1 small interfering RNAYAP 1 small interfering RNA
02
Targets
YAP1 (YES-associated protein–transcriptional enhancer factor domain complex)
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