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siYTHDF3
- Development stage
- Preclinical
- Lead developer
- Kunming Medical University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
siYTHDF3 is a small interfering RNA (siRNA) designed to target and silence the expression of YTH domain family member 3 (YTHDF3), an m6A RNA reader protein. YTHDF3 plays a critical role in promoting epithelial-mesenchymal transition (EMT), tumor growth, and metastasis in breast cancer by binding to m6A-modified Notch2 mRNA and recruiting eIF4B to facilitate its translation. Preclinical studies have evaluated siYTHDF3 encapsulated in lipid nanoparticles (LNPs) for the targeted treatment of breast cancer, demonstrating effective suppression of tumor growth and lung metastasis in vivo.
- Other names
- YTHDF3 siRNAYTHDF-3 siRNAYTHDF 3 siRNAYTHDF3 small interfering RNAYTHDF-3 small interfering RNAYTHDF 3 small interfering RNAsmall interfering RNA targeting YTHDF3
02
Targets
YTHDF3
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