SKF-38393

SKF-38393 is a **synthetic small molecule** of the benzazepine chemical class that acts as a **selective partial agonist at dopamine D1-like receptors** (primarily the D1 and D5 subtypes). It is commonly used as a pharmacological tool in research to investigate dopaminergic mechanisms due to its receptor specificity. SKF-38393 exhibits **stimulant and anorectic (appetite-suppressing) effects**, and has been studied for its potential neuroprotective actions in models of Parkinson’s disease. It does not activate D2-like receptors, distinguishing it from many other dopaminergic agents. The compound and several of its derivatives were originally developed by GSK and are widely available for experimental use in neuroscience and pharmacology[1][3][5][7].

Other names

1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineSKF-38393 hydrobromideSKF38393 hydrobromideSKF 38393 hydrobromideS(-)-SKF-38393 HCL(±)-SKF-38393 hydrochloride