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SKIC-02
- Development stage
- Unknown
- Lead developer
- West China Hospital of Sichuan University
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
SKIC-02 is an investigational mRNA-based therapeutic designed to target C-type lectin-like molecule-1 (CLL1, also known as CLEC12A) and Fms-like tyrosine kinase 3 (FLT3). Developed by West China Hospital of Sichuan University, it is being evaluated for the treatment of relapsed or refractory intermediate-to-high risk acute myeloid leukemia (AML). The drug utilizes mRNA technology to potentially express therapeutic proteins that engage the immune system against AML cells expressing CLL1 and FLT3, which are frequently overexpressed in leukemic stem cells and blasts. It is currently being studied in a Phase 1 exploratory trial in China to assess safety, tolerability, and preliminary efficacy.
- Other names
- CLL1/FLT3-targeted mRNA therapeutic
02
Targets
CLEC12AFLT3 (Fms related receptor tyrosine kinase 3)
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