Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
SKP2-CKS1 program
- Development stage
- Preclinical
- Lead developer
- Iktos
- Modality
- Small Molecules
01
Overview
The SKP2-CKS1 program is an AI-driven drug discovery initiative by Iktos focused on developing small-molecule inhibitors of the protein-protein interaction (PPI) between S-phase kinase-associated protein 2 (SKP2) and cyclin-dependent kinase regulatory subunit 1 (CKS1). This interaction is a critical component of the SCF-Skp2/Cks1 E3 ubiquitin ligase complex, which targets the tumor suppressor protein p27 for degradation. By disrupting this PPI, the inhibitors aim to stabilize p27 levels, leading to cell cycle arrest and inhibition of tumor growth in cancers dependent on the Skp2-p27 axis. Iktos utilizes its proprietary generative AI platform, Makya, and synthesis planning tool, Spaya, along with MTBench cellular technology to identify and optimize these novel PPI inhibitors.
- Other names
- SKP2-CKS1 PPI inhibitorSKP-2-CKS1 PPI inhibitorSKP 2-CKS1 PPI inhibitor
02
Targets
SKP2/CKS1 (SKP2–CKS1 interface)
Beyond the preview
Go deeper on SKP2-CKS1 program.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SKP2-CKS1 program.