SL0101

SL0101 is a selective, cell-permeable inhibitor of the p90 ribosomal S6 kinase (RSK) family, originally isolated from the tropical plant *Forsteronia refracta*. It functions as an ATP-competitive inhibitor that specifically targets the N-terminal kinase domain of RSK1 and RSK2. In preclinical research, SL0101 has been shown to impair the proliferation of various cancer cell lines, including glioblastoma, breast, and prostate cancer, by modulating the Ras-ERK signaling pathway. While it is widely utilized as a chemical probe to study RSK-dependent biological processes, its development as a therapeutic agent has been limited by poor pharmacokinetic properties and metabolic instability.

Other names

kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)